Secretor status controls mucosal histoblood group antigen expression and is associated with susceptibility to rotavirus diarrhea, with non-secretors less susceptible to symptomatic infection. The role of breast milk secretor status on oral live-attenuated rotavirus vaccine response in breastfed infants has not been explored. In a monovalent G1P[8] rotavirus vaccine (Rotarix^TM) trial in Bangladesh, rotavirus-specific plasma IgA antibody seroconversion rates were higher among infants of maternal non-secretors (39% vs 23%, P=0.001). Maternal status remained a significant predictor when correcting for infant status (P=0.002). Maternal secretor status should be considered when interpreting oral rotavirus vaccine responses in low- and middle-income settings.

中文翻译：

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母体分泌状态影响孟加拉国母乳喂养婴儿的口服轮状病毒疫苗反应。

分泌状态控制黏膜组织血型抗原的表达，并与轮状病毒腹泻的易感性有关，非分泌型对症状性感染的敏感性较低。母乳分泌状态对母乳喂养婴儿口服减毒轮状病毒疫苗反应的作用尚未研究。在孟加拉国进行的单价 G1P[8] 轮状病毒疫苗 (Rotarix ^TM ) 试验中，母体非分泌型婴儿的轮状病毒特异性血浆 IgA 抗体血清转化率较高（39% 对 23%，P=0.001）。在校正婴儿状态时，母体状态仍然是一个重要的预测因子（P=0.002）。在解释中低收入环境中的口服轮状病毒疫苗反应时，应考虑母体分泌状态。