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Consequences of Undervaccination — Measles Outbreak, New York City, 2018–2019
The New England Journal of Medicine ( IF 70.670 ) Pub Date : 2020-03-12 , DOI: 10.1056/nejmoa1912514
Jane R. Zucker; Jennifer B. Rosen; Martha Iwamoto; Robert J. Arciuolo; Marisa Langdon-Embry; Neil M. Vora; Jennifer L. Rakeman; Beth M. Isaac; Antonine Jean; Mekete Asfaw; Simone C. Hawkins; Thomas G. Merrill; Maura O. Kennelly; Beth Maldin Morgenthau; Demetre C. Daskalakis; Oxiris Barbot

Background Measles was declared eliminated in the United States in 2000, but the risk of outbreaks owing to international importations remains. An outbreak of measles in New York City began when one unvaccinated child returned home from Israel with measles; onset of rash occurred on September 30, 2018, 9 days after the child returned home. Methods We investigated suspected cases of measles by conducting interviews, reviewing medical and immunization records, identifying exposed persons, and performing diagnostic testing. Measles–mumps–rubella (MMR) vaccine (given as either MMR or measles–mumps–rubella–varicella vaccine and collectively referred to as MMR vaccine) uptake was monitored with the use of the Citywide Immunization Registry. The total direct cost to the New York City Department of Health and Mental Hygiene was calculated. Results A total of 649 cases of measles were confirmed, with onsets of rash occurring between September 30, 2018, and July 15, 2019. A majority of the patients (93.4%) were part of the Orthodox Jewish community, and 473 of the patients (72.9%) resided in the Williamsburg area of Brooklyn, New York. The median age was 3 years; 81.2% of the patients were 18 years of age or younger, and 85.8% of the patients with a known vaccination history were unvaccinated. Serious complications included pneumonia (in 37 patients [5.7%]) and hospitalization (in 49 patients [7.6%]); among the patients who were hospitalized, 20 (40.8%) were admitted to an intensive care unit. As a result of efforts to promote vaccination, the percentage of children in Williamsburg who received at least one dose of MMR vaccine increased from 79.5% to 91.1% among children 12 to 59 months of age. As of September 9, 2019, a total of 559 staff members at the Department of Health and Mental Hygiene (7% of the agency) had been involved in the measles response. The cost of the Department of Health and Mental Hygiene response was $8.4 million. Conclusions Importation of measles and vaccination delays among young children led to an outbreak of measles in New York City. The outbreak response was resource intensive and caused serious illness, particularly among unvaccinated children.
更新日期:2020-03-12

 

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