Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a potentially life-threatening hypersensitivity reaction characterized by skin eruption, fever, hematologic abnormalities, and multiorgan involvement. If unrecognized, this condition may be fatal, with a mortality rate of up to 10%.¹ Treatment involves discontinuation of treatment with the culprit drug, supportive care, and in severe eruptions with end-organ dysfunction, systemic immunosuppression with glucocorticoids. However, patients with contraindications to glucocorticoids may benefit from treatment with cyclosporine, a calcineurin inhibitor with anti-apoptotic effects on cytotoxic T cells. Cyclosporine also inhibits production of interleukin-5, which generates eosinophilia and drug-specific T cells that mediate DRESS.² While cyclosporine represents an alternative treatment for DRESS, little is known about its utility.^3,4

嗜酸性粒细胞增多和全身症状（DRESS）综合征的药物反应是一种潜在的威胁生命的超敏反应，其特征是皮肤喷发，发烧，血液学异常和多器官受累。如果无法识别，这种情况可能是致命的，死亡率高达10％。¹治疗包括终止使用罪魁祸首药物的治疗，支持治疗，以及在发作严重且终末器官功能不全的情况下，应用糖皮质激素进行全身性免疫抑制。但是，有糖皮质激素禁忌症的患者可能会受益于环孢素的治疗，环孢素是一种钙调神经磷酸酶抑制剂，对细胞毒性T细胞具有抗凋亡作用。环孢菌素还抑制白介素5的产生，白细胞介素5产生嗜酸性粒细胞增多和介导DRESS的药物特异性T细胞。²尽管环孢菌素是DRESS的替代疗法，但对其效用知之甚少。^{3 ，4}