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Genetic polymorphisms and multiple myeloma risk: a meta-analysis.
Annals of Hematology ( IF 3.5 ) Pub Date : 2020-03-11 , DOI: 10.1007/s00277-020-03979-7
Pengcheng Zhang 1, 2, 3 , Bing Liu 2, 3
Affiliation  

Previous researches exploring associations between multiple myeloma (MM) and genetic polymorphisms showed controversial results. In this investigation, we aimed to make a meta-analysis to assess the association between MM risk and genetic polymorphisms. We searched for articles on genetic polymorphism and MM risk in Web of Science and PubMed databases from 1951 to August 2019. We computed the odds ratio (OR) and 95% confidence intervals (CI) extracted from included articles. The meta-analysis showed no significant associations between MM risks and tumor necrosis factor (TNF)-α (rs1800629/rs361525/rs1799724), interleukin (IL)-6 (rs1800795), multidrug resistance 1 (MDR1) (rs1045642), Methylenetetrahydrofolate reductase (MTHFR) (rs1801131/rs1801133) polymorphisms. In summary, the study shows that the TNF-α (rs1800629/rs361525/rs1799724), IL-6 (rs1800795), MDR1 (rs1045642), and MTHFR (rs1801131/rs1801133) polymorphisms may not be associated with MM susceptibility. Thus, we do not need more expensive and useless studies to explore the associations between MM risks and these genetic polymorphisms.

中文翻译:

遗传多态性和多发性骨髓瘤的风险:一项荟萃分析。

先前研究探索多发性骨髓瘤(MM)与遗传多态性之间的关联的研究显示了有争议的结果。在这项调查中,我们旨在进行荟萃分析,以评估MM风险与遗传多态性之间的关联。我们从1951年至2019年8月在Web of Science和PubMed数据库中搜索有关遗传多态性和MM风险的文章。我们计算了从纳入文章中提取的比值比(OR)和95%置信区间(CI)。荟萃分析显示MM风险与肿瘤坏死因子(TNF)-α(rs1800629 / rs361525 / rs1799724),白介素(IL)-6(rs1800795),多药耐药性1(MDR1)(rs1045642),亚甲基四氢叶酸还原酶之间无显着相关性(MTHFR)(rs1801131 / rs1801133)多态性。总之,研究表明TNF-α(rs1800629 / rs361525 / rs1799724)IL-6(rs1800795),MDR1(rs1045642)和MTHFR(rs1801131 / rs1801133)多态性可能与MM易感性无关。因此,我们不需要更昂贵和无用的研究来探索MM风险与这些遗传多态性之间的关联。
更新日期:2020-03-11
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