Here, we report that chitosan can mediate assembly of poly (vinyl alcohol-co-ethylene) (PVA-co-PE) nanofiber via a green and facile electrodeposition approach, and forming a nanocomposite film with enhanced mechanical property and pH-dependent permeability. Several measurements suggest the film growth (eg. thickness) is linearly correlated to the imposed charge transfer and can be well quantified by using a moving front model. Morphological observations reveal that the nanofibers are evenly distributed throughout of the films and formed with novel fiber/polymer architecture. Swelling ratio and water flux measurements indicate the film permeation property was greatly influenced by the nanofiber contents and environmental pH cues. The incorporated nanofiber leads to a higher protein loading capacity of 1.38 μg/cm² (eg. Insulin) and allows a sustained release from the confined internal microporous structure over 24 h. In addition, above release behaviors can be programmed according to externally imposed electrical signals. Thus, coupling chitosan-mediated assembly of nanofibers with the electrochemically controlled release system provides great possibilities for multi-functional coatings and drug elution on conductive implants.

在这里，我们报道壳聚糖可以介导聚（乙烯醇-共-乙烯）（PVA-共-PE）纳米纤维，通过绿色便捷的电沉积方法形成具有增强的机械性能和pH依赖性渗透性的纳米复合薄膜。几次测量表明，薄膜的生长（例如厚度）与施加的电荷转移呈线性关系，可以通过使用移动前沿模型很好地量化。形态学观察表明，纳米纤维均匀地分布在整个薄膜中，并形成了新颖的纤维/聚合物结构。溶胀率和水通量测量结果表明，膜渗透性能受纳米纤维含量和环境pH提示的影响很大。掺入的纳米纤维导致更高的蛋白质负载能力1.38μg/ cm ²（例如胰岛素），并在24小时内从受限的内部微孔结构中持续释放。此外，可以根据外部施加的电信号对上述释放行为进行编程。因此，将壳聚糖介导的纳米纤维组装与电化学控制的释放系统耦合，为多功能涂层和导电植入物上的药物洗脱提供了极大的可能性。