Pathogens rely on nutrient assimilation, particularly essential metal incorporation, to successfully survive in the host. In this issue of Cell Host & Microbe, Riedelberger et al. (2020) convincingly demonstrate that type I interferons (IFNs-I) promote dysregulation of iron homeostasis in macrophages upon infection with Candida glabrata and exacerbate infection.

中文翻译：

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铁拳一型干扰素规则

病原体依靠营养同化，尤其是必需的金属掺入，才能在宿主中成功存活。在本期《细胞宿主与微生物》中，Riedelberger等人。（2020）令人信服地证明，I型干扰素（IFNs-I）会在光滑念珠菌感染后促进巨噬细胞中铁稳态的失调，并加剧感染。