Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that regulates lymphocyte trafficking, glial cell activation, vasoconstriction, endothelial barrier function, and neuronal death pathways in the brain. Research has increasingly implicated S1P in the pathology of cerebral ischemia reperfusion (IR) injury. As a high-affinity agonist of S1P receptor, fingolimod exhibits excellent neuroprotective effects against ischemic challenge both in vivo and in vitro. By summarizing recent progress on how S1P participates in the development of brain IR injury, this review identifies potential therapeutic targets for the treatment of brain IR injury.

1-磷酸鞘氨醇（S1P）是一种具有生物活性的鞘脂，可调节淋巴细胞的运输，神经胶质细胞的活化，血管收缩，内皮屏障的功能以及大脑中神经元的死亡途径。研究越来越多地将S1P牵涉到脑缺血再灌注（IR）损伤的病理学中。作为S1P受体的高亲和性激动剂，芬戈莫德在体内和体外均表现出出色的抗缺血性攻击的神经保护作用。通过总结有关S1P如何参与脑IR损伤发展的最新进展，本综述确定了治疗脑IR损伤的潜在治疗靶标。