Acacia catechu (A. catechu) or Khair (Hindi) is used in several herbal preparations in the Ayurvedic system of medicine in India. Traditionally, this drug is beneficial against several gastrointestinal and stomach related ailments, and leprosy. The present investigation was carried out to evaluate the sub-acute oral toxicity of the ethanolic extract of A. catechu seeds in Wistar albino rats. Results obtained from the quantitative chemical analysis of A. catechu seed extract were compared with commercially available standards. A. catechu seed extract was administered orally at the doses of 250, 500 and 1000 mg/kg b.w. daily for 28 days. General behavior, bodyweight and mortality were examined during the entire study period. At the end of 28 days, hematological and biochemical parameters along with the relative organ weights were determined. It was observed that the extract did not induce death or any significant changes in the body weight, relative weight of vital organs and in hematological parameters for up to a dose of 1000 mg/kg. The oral administration of the plant extract did not produce any significant changes in the levels of glucose. In addition, there were no significant changes in the activity of both hepatotoxic and nephrotoxic marker enzymes in the serum. Oral administration of A. catechu also did not produce any significant changes in the levels of oxidative markers. Furthermore, the findings from the biochemical studies were, well corroborated with the histological findings.

中文翻译：

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评估Wistar白化病大鼠模型中金合欢（Acacia catechu）Willd种子提取物的亚急性毒性。

印度的阿育吠陀医学系统中的几种草药制剂中都使用了刺槐（A. catechu）或凯尔（Hindi）。传统上，该药物对多种胃肠道和胃相关疾病以及麻风病有益。进行本研究以评估Wistar白化病大鼠中儿茶曲霉种子乙醇提取物的亚急性口服毒性。将儿茶曲霉种子提取物的定量化学分析结果与市售标准品进行比较。每天以250、500和1000 mg / kg bw的剂量口服给予儿茶种子提取物，持续28天。在整个研究期间检查了一般行为，体重和死亡率。在28天结束时，测定血液学和生化参数以及相对器官重量。观察到在最高剂量为1000 mg / kg时，提取物不会引起死亡或体重，重要器官的相对重量和血液学参数的任何显着变化。口服施用植物提取物并未使葡萄糖水平产生任何显着变化。此外，血清中肝毒性和肾毒性标记酶的活性均无显着变化。儿茶曲霉的口服给药也未在氧化标志物水平上产生任何显着变化。此外，生化研究的结果与组织学结果得到了很好的证实。口服施用植物提取物并未使葡萄糖水平产生任何显着变化。此外，血清中肝毒性和肾毒性标记酶的活性均无显着变化。儿茶曲霉的口服给药也未在氧化标志物水平上产生任何显着变化。此外，生化研究的结果与组织学结果得到了很好的证实。口服施用植物提取物并未使葡萄糖水平产生任何显着变化。此外，血清中肝毒性和肾毒性标记酶的活性均无显着变化。儿茶曲霉的口服给药也未在氧化标志物水平上产生任何显着变化。此外，生化研究的结果与组织学结果得到了很好的证实。