Herein, we describe a chemoselective, regioselective, modular, and efficient deconstructive oxo-halogenation strategy, which skeletally remodels readily available cyclic α-alkynyl eneformamides into formamide-tethered α-halo ynones. This scaffold-hopping transformation furnishes diverse architectures that would be challenging to achieve through traditional disconnections.

中文翻译：

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通过易于获得的α-炔基烯甲酰胺的解构性卤化羰基化连接甲酰胺束缚的α-卤代炔酮

在本文中，我们描述了一种化学选择性，区域选择性，模块化和高效解构的氧代卤代化策略，该策略通过骨架将易得的环状α-炔基烯甲酰胺重塑为甲酰胺束缚的α-卤代炔酮。这种脚手架的转换提供了多种架构，而这些架构将很难通过传统的断开连接来实现。