The antifouling properties of poly(ethylene oxide) (PEO)-silane amphiphiles as surface-modifying additives (SMAs) in a condensation cure silicone have been previously demonstrated against simple protein solutions. Comprising an oligo(dimethylsiloxane) tether (m = 13 or 30) and PEO segment (n = 8), sustained protein resistance was achieved even in the absence of a cross-linkable triethoxysilane group, particularly when comprising the longer tether. To probe their potential for thromboresistance, PEO-silane amphiphile SMAs were used to bulk-modify silicones and evaluated for adhesion resistance against whole human blood under both static and dynamic conditions. Both a cross-linkable (XL diblock, m = 13) and a non-cross-linkable (Diblock, m = 30) SMA were evaluated at various concentrations (5–50 μmol SMA/g silicone) in a condensation cure silicone. Under static conditions, silicones modified with either SMA at concentrations of 10 μmol/g or greater were effective in reducing adhesion of human fibrinogen and platelets. Dynamic testing further showed that modified silicones were able to reduce protein adsorption and thrombus formation. This occurred at 5 and 10 μmol/g for silicones modified with XL diblock, m = 13 and Diblock, m = 30 SMAs, respectively. Combined, these results indicate the effectiveness of PEO-silane amphiphiles as SMAs in silicone for improved thromboresistance.

中文翻译：

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PEO-硅烷两亲物改性的有机硅的抗血栓性

先前已经证明了聚（环氧乙烷）（PEO）-硅烷两亲物作为缩合固化有机硅中的表面改性添加剂（SMA）的防污性能，可针对简单的蛋白质溶液进行验证。包含低聚（二甲基硅氧烷）系链（m = 13或30）和PEO链段（n = 8），即使不存在可交联的三乙氧基硅烷基团，尤其是包含较长的系链时，仍可实现持续的蛋白抗性。为了探测其潜在的抗血栓形成性，PEO-硅烷两亲性SMA被用于大量改性有机硅，并评估了其在静态和动态条件下对全人类血液的附着力。可交联的（XL diblock，m = 13）和不可交联的（Diblock，m= 30）在缩合固化有机硅中以各种浓度（5–50μmolSMA / g硅树脂）评估SMA。在静态条件下，用SMA改性的有机硅在10μmol/ g或更高的浓度下可有效减少人纤维蛋白原和血小板的粘附。动态测试进一步表明，改性有机硅能够减少蛋白质吸附和血栓形成。对于用XL diblock（m = 13）和Diblock（m = 30 SMA）改性的有机硅，这种情况分别发生在5和10μmol/ g 。结合起来，这些结果表明，PEO-硅烷两亲物作为有机硅中的SMA可有效改善抗血栓形成性。