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Decoration of Material Surfaces with Complex Physicochemical Signals for Biointerface Applications
ACS Biomaterials Science & Engineering ( IF 5.8 ) Pub Date : 2020-03-10 , DOI: 10.1021/acsbiomaterials.9b01806
Yue Shi, Kun Liu, Zhen Zhang, Xuelian Tao, Hsien-Yeh Chen, Peter Kingshott, Peng-Yuan Wang

The surface properties of biomaterials are crucial at controlling biological interactions. Cells or tissues sense different stimuli from surfaces and respond accordingly. A number of studies have reported that fabricating complex stimuli-presenting surfaces is beneficial for mimicking and understanding the in vivo scenario where multi-physicochemical cues are present. Biological responses toward these surfaces could be either negative, such as immune responses, or positive, such as tissue regeneration. An ideal material surface should, therefore, be multifunctional, triggering the desired biological process and suppressing the unwanted side effects. The methods for material surface decoration can be very sophisticated, depending on the applications such as biosensors, medical devices, and/or implants. To date, decorating material surfaces with complex chemistries and topographies is still challenging, and methods are not straightforward. The majority of the methods require multiple steps and combinational approaches that include mask-based techniques, lithography, wet or dry etching, wet chemistry, or vapor-based coatings, among others. Although these methods have been established in the laboratory, easy-to-access and straightforward approaches need to be explored. This Review summarizes the state-of-the-art techniques for generating patterned multichemical and multitopographic signals on material surfaces, and the potential of having these surfaces in biointerface applications.

中文翻译:

用于生物界面应用的具有复杂物理化学信号的材料表面装饰

生物材料的表面特性对于控制生物相互作用至关重要。细胞或组织从表面感觉到不同的刺激并做出相应的反应。许多研究报告说,制造复杂的刺激呈现表面有利于模仿和理解存在多种物理化学线索的体内情况。对这些表面的生物反应可能是阴性(例如免疫反应),也可能是阳性(例如组织再生)。因此,理想的材料表面应该是多功能的,从而触发所需的生物过程并抑制有害的副作用。材料表面装饰的方法可能非常复杂,具体取决于诸如生物传感器,医疗设备和/或植入物的应用。至今,用复杂的化学和形貌装饰材料表面仍然具有挑战性,而且方法也不简单。大多数方法需要多个步骤和组合方法,包括基于掩模的技术,光刻,湿法或干法蚀刻,湿法化学或基于蒸汽的涂层等。尽管这些方法已在实验室中建立,但仍需要探索易于访问和直接的方法。这篇综述总结了在材料表面上生成图案化的多化学和多形信号的最新技术,以及在生物界面应用中具有这些表面的潜力。大多数方法需要多个步骤和组合方法,其中包括基于掩模的技术,光刻,湿法或干法蚀刻,湿法化学或基于蒸汽的涂层等。尽管这些方法已在实验室中建立,但仍需要探索易于访问和直接的方法。这篇综述总结了在材料表面上生成带图案的多化学和多形信号的最新技术,以及在生物界面应用中具有这些表面的潜力。大多数方法需要多个步骤和组合方法,其中包括基于掩模的技术,光刻,湿法或干法蚀刻,湿法化学或基于蒸汽的涂层等。尽管这些方法已在实验室中建立,但仍需要探索易于访问和直接的方法。这篇综述总结了在材料表面上生成带图案的多化学和多形信号的最新技术,以及在生物界面应用中具有这些表面的潜力。
更新日期:2020-04-23
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