BACKGROUND Bladder cancer (BC) patients with advanced disease have poor outcomes. The use of patient-reported outcomes (PROs) could lead to improvements in symptom management and hence quality of life (QoL). The aim of this study is to report correlations between selected PROs and QoL and thus to present symptoms that influence QoL. Identification of these symptoms during treatment can lead to earlier symptom management and thus secure improvements in QoL. METHODS BC patients in chemo- or immunotherapy for locally advanced or metastatic disease reported weekly PROs for the duration of their treatment. The PROs included EORTC QLQ-C30 and QLQ-BLM30 and 45 selected PRO-CTCAE items. Spearman's correlation analysis was performed for all PRO-CTCAE items and QLQ-C30 global QoL and subdomains. RESULTS In this study, 78 BC patients reported 724 questionnaires. Spearman's analysis showed significant correlations between almost all PRO-CTCAE items and the expected domain of QoL. The PRO-CTCAE items with the strongest correlations with QoL were anxiety (F, frequency item) and emotional function (rs = -0.603, P < .0001), concentration (S, severity item) and cognitive function (rs = -0.704, P < .0001), discouraged (F) and emotional function (rs = -0.659, P < .0001), fatigue (S) and role function (rs = -0.659, P < .0001) and sad (F) and emotional function (rs = -0.711, P < .0001). The weakest correlations were found for the PRO-CTCAE items urinary frequency, incontinence and urge, all with variations in the direction and significance of the correlations. CONCLUSIONS This study delivers information on which PROs may influence QoL for patients in clinical trials or daily clinic. Psychological issues have a strong impact on QoL and should be dealt with during treatment to secure the best possible QoL for BC patients.

中文翻译：

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患者报告了患有晚期疾病的膀胱癌患者在化学疗法或免疫疗法期间与生活质量相关的症状。

背景技术患有晚期疾病的膀胱癌（BC）患者预后较差。使用患者报告的结局（PRO）可以改善症状管理，从而改善生活质量（QoL）。这项研究的目的是报告选定的PRO和QoL之间的相关性，从而提出影响QoL的症状。在治疗期间对这些症状的识别可以导致较早的症状管理，从而可以确保QoL的改善。方法在接受化学疗法或免疫疗法治疗的局部晚期或转移性疾病的BC患者中，每周报告其治疗期间的PRO。PRO包括EORTC QLQ-C30和QLQ-BLM30以及45个选定的PRO-CTCAE项目。对所有PRO-CTCAE项目以及QLQ-C30全局QoL和子域执行Spearman的相关性分析。结果在这项研究中，78位卑诗省患者报告了724份问卷。Spearman的分析表明，几乎所有PRO-CTCAE项目与预期QoL域之间都存在显着相关性。与QoL相关性最强的PRO-CTCAE项目是焦虑（F，频率项目）和情绪功能（rs = -0.603，P <.0001），注意力（S，严重程度项目）和认知功能（rs = -0.704， P <.0001），沮丧（F）和情感功能（rs = -0.659，P <.0001），疲劳（S）和角色功能（rs = -0.659，P <.0001）和悲伤（F）和情感函数（rs = -0.711，P <.0001）。在PRO-CTCAE项目的尿频，尿失禁和冲动中发现了最弱的相关性，所有这些相关性的方向和重要性都有变化。结论本研究提供了有关哪些PRO可能会影响临床试验或日常诊所患者QoL的信息。心理问题对QoL有很大影响，应在治疗期间加以处理，以确保BC患者获得最佳的QoL。