A facile approach to chiral dihydroquinazolinone derivatives has been described via biomimetic asymmetric reduction of quinazolinones with chiral and regenerable NAD(P)H models. The utility of this method was demonstrated by a concise synthesis of the bromodomain protein divalent inhibitor.

中文翻译：

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手性和可再生NAD（P）H模型的仿生不对称还原喹唑啉酮

通过手性和可再生的NAD（P）H模型通过仿生不对称还原喹唑啉酮，已经描述了一种简便的手性二氢喹唑啉酮衍生物的方法。溴结构域蛋白二价抑制剂的简明合成证明了该方法的实用性。