Abstract

Purpose

Given the rarity in the population with adult thalamic gliomas (ATGs), comprehensive characteristics, treatments and survival outcome are not well characterized. This study was conducted to investigate the comprehensive characteristic and treatment of ATGs and identify the prognostic factors associated with overall survival (OS).

Methods

A retrospective analysis of newly diagnosed ATGs who underwent surgical resection consecutively was conducted. Survival analysis of OS was performed by Kaplan–Meier analysis. Cox proportional hazard model was used to investigate the possible prognostic factors associated with OS.

Results

A total of 102 patients with ATG were enrolled in this study. The median age was 41 years (range 18–68 years). There were 56 (54.9%) males. Sixty-two patients (60.8%) had glioblastoma (GBM). Among these patients, 46 patients (45.1%) had GTR/NTR, 50 patients (49.0%) had STR and 6 patients (5.9%) had PR. Postoperatively, 71.6% of these patients received adjuvant therapy. The median OS was 13.6 months (range 1 week–75 months). COX regression analysis revealed that ATG patients with longer duration of symptoms (p = 0.024), better pre-KPS (p = 0.045), maximal resection (p = 0.013), or lower tumor grade (p = 0.002) had longer OS, and these predictors are considered as independent prognostic factors. Survival analysis showed that ATGs with GTR/NTR plus chemoradiotherapy had significant OS advantage compared with other treatment regimens.

Conclusions

This study comprehensively summarized the characteristics, treatments and survival outcomes of ATGs in the largest sample size. Maximal surgical resection can bring survival benefit. Combined-modality therapy regimen of GTR/NTR plus chemoradiotherapy may be better beneficial for OS than other regimens.

中文翻译：

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成人丘脑神经胶质瘤的手术治疗和生存结果：单机构工作经验达8年。

摘要

目的

鉴于成人丘脑神经胶质瘤（ATG）的稀有性，综合特征，治疗和生存结局并没有很好的特征。进行这项研究以调查ATG的综合特征和治疗方法，并确定与总生存期（OS）相关的预后因素。

方法

对连续接受手术切除的新诊断的ATG进行回顾性分析。通过Kaplan–Meier分析进行OS生存分析。使用Cox比例风险模型研究与OS相关的可能预后因素。

结果

本研究共纳入102名ATG患者。中位年龄为41岁（范围18-68岁）。男56（54.9％）。62名患者（60.8％）患有胶质母细胞瘤（GBM）。在这些患者中，有46例（45.1％）患有GTR / NTR，50例（49.0％）患有STR，6例（5.9％）患有PR。术后有71.6％的患者接受了辅助治疗。中位OS为13.6个月（范围为1周至75个月）。COX回归分析显示，症状持续时间较长（p = 0.024），KPS前较好（p = 0.045），最大切除率（p = 0.013）或肿瘤分级较低（p = 0.002）的ATG患者的OS较长，并且这些预测因素被认为是独立的预后因素。生存分析表明，与其他治疗方案相比，GTR / NTR联合放化疗治疗的ATG具有显着的OS优势。

结论

这项研究全面总结了最大样本量的ATG的特征，治疗方法和生存结果。最大程度的手术切除可以带来生存益处。GTR / NTR联合放化疗联合化疗可能比其他方案对OS更好。