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Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies.
Emerging Infectious Diseases ( IF 11.8 ) Pub Date : 2020-05-17 , DOI: 10.3201/eid2605.190921
Nisreen M.A. Okba , Ivy Widjaja , Wentao Li , Corine H. GeurtsvanKessel , Elmoubasher A.B.A. Farag , Mohammed Al-Hajri , Wan Beom Park , Myoung-don Oh , Chantal B.E.M. Reusken , Marion P.G. Koopmans , Berend-Jan Bosch , Bart L. Haagmans

We developed and validated 2 species-independent protein-based assays to detect Middle East respiratory syndrome coronavirus functional antibodies that can block virus receptor-binding or sialic acid-attachment. Antibody levels measured in both assays correlated strongly with virus-neutralizing antibody titers, proving their use for serologic confirmatory diagnosis of Middle East respiratory syndrome.

中文翻译:

中东呼吸综合征冠状病毒功能抗体的血清学检测。

我们开发并验证了2种基于物种的独立蛋白检测方法,以检测可阻断病毒受体结合或唾液酸附着的中东呼吸综合征冠状病毒功能抗体。两种测定中测得的抗体水平与病毒中和抗体滴度密切相关,证明它们可用于中东呼吸综合征的血清学确诊。
更新日期:2020-04-16
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