Caries preventive effect of a sugar-free chewing-gum containing Magnolia Bark Extracts and Xylitol in high-risk adults was investigated (NCT02310308). Two-hundred seventy-one high-caries-risk subjects were assigned to three groups: Polyols (Pols), Xylitol (Xyl) and Xylitol plus Magnolia (Xyl + Mag). Caries lesions, gingival bleeding, mutans streptococci (MS), and plaque pH were re-evaluated after 2 years in 64 Pols, 66 Xyl and 64 Xyl + Mag subjects. Net caries increment was evaluated using the Mann–Whitney U test. Caries increment was significantly different among groups at the 2-year evaluation (t₃) (p < 0.01). MS concentration and plaque pH as mean Areas Under the Curves (AUC) differed among groups at t₂ (MS p = 0.02, AUC_5.7 p = 0.03 and AUC_6.2 p = 0.04,) and t₃ (p = 0.03, p = 0.04 and 0.05, respectively). Significantly lower gingival scores were observed in Xyl + Mag and Xyl groups (p = 0.01 and <0.01, respectively). Chewing-gum containing Xylitol and Magnolia has a higher preventive effect compared to Xylitol alone.

研究了含木兰皮提取物和木糖醇的无糖口香糖在高危成年人中的龋齿预防作用（NCT02310308）。271名高危人群被分为三组：多元醇（Pols），木糖醇（Xyl）和木糖醇加木兰（Xyl + Mag）。在64名Pols，66个Xyl和64个Xyl + Mag受试者中，两年后重新评估了龋损，牙龈出血，变形链球菌（MS）和噬菌斑pH。使用Mann–Whitney U检验评估净龋齿增量。在2年评估中，各组之间的龋齿增量显着不同（t ₃）（p <0.01）。各组在t _2时， MS浓度和噬菌斑pH曲线下平均面积（AUC）有所不同（MS p = 0.02，AUC _5.7p = 0.03和AUC _6.2 p = 0.04，）和t ₃（p = 0.03，p = 0.04和0.05）。在Xyl + Mag和Xyl组中，牙龈得分明显降低（分别为p = 0.01和<0.01）。与单独的木糖醇相比，含有木糖醇和木兰的口香糖具有更高的预防作用。