Ti-15Zr-xCu (3 ≤ x ≤ 7, wt.%) novel antibacterial and antibiofilm alloys with competitive mechanical properties, biological responses and corrosion resistance were designed and fabricated. Annealing heat treatment on Ti-15Zr-7Cu (TZC-7A), after holding for 2 h at slightly above their beta transus temperature (BTT) ensured their tensile strength (UTS), yield strength (YS) and hardness (HRV) were improved by 31.2%, 20% and 12.3% respectively compared to the control without Cu, Ti-15Zr (T-15ZA). Although the 3 wt.% Cu alloy displayed the highest elongation (26%), the TZC-7A alloy also possessed a good ductility. Presence of evenly dispersed Ti₂Cu and Zr₂Cu Cu-rich intermetallic phases formed as interwoven and alternating lamellae within the α + β matrix as a result of Cu addition, as revealed by X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). These greatly contributed to their strengthening and bactericidal properties. Over 98% antibacterial effect against E. coli and S. aureus have been imparted, coupled with excellent biofilm inhibition. Potentiodynamic polarization curves showed that the TZC-7A alloy possessed higher corrosion resistance than commercially pure titanium, cp-Ti; contact angle test revealed enhanced hydrophilicity; while confocal laser scanning microscopy (CLSM) and cell counting kit (CCK-8) assays also displayed drastically lowered bacterial adhesion rate with comparatively no cytotoxicity. Cell attachment on all alloys was similar but the best spread was obtained on TZC-7A after 24 h. The developed alloy has good potential as an antibacterial implant material with combination of optimized properties.

的Ti-15Zr- X的Cu（3≤ X ≤7，重量％）有竞争力的机械性能，生物反应和耐腐蚀性新型抗菌和抗生物膜合金设计和制造。在Ti-15Zr-7Cu（TZC-7A）上稍高于其β转变温度（BTT）保持2小时后，进行退火热处理可确保其拉伸强度（UTS），屈服强度（YS）和硬度（HRV）得到改善与不含Cu，Ti-15Zr（T-15ZA）的对照相比，分别降低了31.2％，20％和12.3％。尽管3 wt。％的Cu合金显示出最高的伸长率（26％），但TZC-7A合金也具有良好的延展性。存在均匀分散的Ti ₂ Cu和Zr ₂Cu通过X射线衍射（XRD），扫描电子显微镜（SEM）和透射电子显微镜（TEM）揭示，由于添加了Cu，在α+β基体内形成了交织且交替的薄片状的富Cu金属间相。这些极大地促进了它们的增强和杀菌性能。对大肠杆菌和金黄色葡萄球菌的抗菌作用超过98％已被赋予，同时具有出色的生物膜抑制作用。电位动力学极化曲线表明，TZC-7A合金具有比市售纯钛cp-Ti更高的耐蚀性。接触角测试显示亲水性增强；共聚焦激光扫描显微镜（CLSM）和细胞计数试剂盒（CCK-8）分析也显示细菌粘附率大大降低，而没有细胞毒性。所有合金上的细胞附着均相似，但24小时后在TZC-7A上获得了最佳扩散。所开发的合金具有结合优化特性的抗菌植入材料的良好潜力。