MicroRNAs (miRs) are small RNAs modulating gene expression and creating intricate regulatory networks that are dysregulated in many pathological states, including neurodegenerative disorders. In silico analyses denote a multifunctional kinase glycogen synthase kinase-3 (GSK3) as a putative target of numerous miRs identified in neural tissue. GSK3 is engaged in almost all aspects of neuronal development and functioning. Moreover, there is an autoregulatory feedback between GSK3 and miRNAs as the kinase can influence biogenesis of miRs. Members of the miR-GSK3 axes might thus represent convenient therapeutic targets in neuropathologies that display its abnormal regulation. This review summarizes the present knowledge about direct interactions of GSK3 and miRs in brain, and their putative roles in pathogenesis of neurodegenerative and neuropsychiatric disorders. This article is part of a Special Issue entitled: GSK-3 and related kinases in cancer, neurological and other disorders edited by James McCubrey, Agnieszka Gizak and Dariusz Rakus.

中文翻译：

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神经组织中的GSK3和miRNA：从大脑发育到神经退行性疾病。

微小RNA（miRs）是小的RNA，可调节基因表达并创建复杂的调控网络，而调控网络在许多病理状态（包括神经退行性疾病）中均失调。计算机分析表明，多功能激酶糖原合酶激酶-3（GSK3）作为在神经组织中鉴定出的许多miR的假定靶标。GSK3几乎参与神经元发育和功能的所有方面。此外，由于该激酶可以影响miRs的生物发生，因此GSK3与miRNA之间存在自调节反馈。因此，miR-GSK3轴的成员可能代表了表现出异常调节的神经病理学中方便的治疗靶标。这篇综述总结了有关GSK3和miR在大脑中直接相互作用的最新知识，及其在神经变性和神经精神疾病的发病机理中的假定作用。本文是特刊的一部分，该刊物由James McCubrey，Agnieszka Gizak和Dariusz Rakus编辑，题为：癌症，神经系统疾病和其他疾病中的GSK-3和相关激酶。