Extracellular vesicles (EV), which include exosomes and microvesicles, are secreted from virtually every cell. EV contain mRNA, miRNA, lipids and proteins and can deliver this expansive cargo into nearby cells as well as over long distances via the blood stream. Great interest has been given to them for their role in cell to cell communication, disease progression, or as biomarkers, and more recent studies have interrogated their potential as a therapeutic that may replace paracrine-acting cell therapies. The retina is a conveniently accessible component of the central nervous system and the proposed paradigm for the testing of many cell therapies. Recently, several studies have been published demonstrating that the delivery of EV/exosomes into the eye can elicit significant therapeutic effects in several models of retinal disease. We summarize results from currently available studies, demonstrating their efficacy in multiple eye disease models as well as highlighting where future research efforts should be directed.

几乎每个细胞都分泌细胞外囊泡 (EV)，包括外泌体和微泡。EV 含有 mRNA、miRNA、脂质和蛋白质，可以通过血流。由于它们在细胞间通讯、疾病进展或作为生物标志物中的作用，人们对它们产生了极大的兴趣，并且最近的研究已经询问了它们作为可能替代旁分泌作用细胞疗法的治疗剂的潜力。视网膜是中枢神经系统的一个方便访问的组成部分，并且是用于测试许多细胞疗法的建议范式。最近，已发表的几项研究表明，将 EV/外泌体输送到眼睛中可以在几种视网膜疾病模型中产生显着的治疗效果。我们总结了当前可用研究的结果，证明了它们在多种眼病模型中的功效，并强调了未来研究工作的方向。