Novel pyridone EP4 agonists featuring allylic alcohol ω-chains,Bioorganic & Medicinal Chemistry Letters

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Novel pyridone EP4 agonists featuring allylic alcohol ω-chains
Bioorganic & Medicinal Chemistry Letters ( IF 2.7 ) Pub Date : 2020-03-10 , DOI: 10.1016/j.bmcl.2020.127104
Stéphane Dorich , Jennifer H. Cox , Jason D. Burch , Félix Chagnon , Bin Chen , Serge Léger , Miguel St-Onge , Lee D. Fader

Novel prostaglandin E2 receptor 4 (EP₄) agonists featuring a pyridone core and an allylic alcohol ω-chain were discovered. These agonists were shown to be selective over EP₁, EP₂ and EP₃. Analogs harboring a 4-carboxylic acid phenethyl α-chain displayed improved potency over those containing an n-heptanoic acid chain. Key SAR relationships were also identified2019 Elsevier Ltd. All rights reserved

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