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Palladium-Catalyzed Fluoroacylation of (Hetero)arylboronic Acid with Fluorothioacetates at Ambient Temperature
Tetrahedron Letters ( IF 1.8 ) Pub Date : 2020-03-09 , DOI: 10.1016/j.tetlet.2020.151780
Xing Yi , Ya-Fang Cao , Xing Wang , Hui Xu , Shu-Rong Ban , Hui-Xiong Dai

A palladium-catalyzed fluoroacylation of (hetero)aryl boronic acid with the fluorothioacetates is described at ambient temperature. A variety of aryl, and heteroaryl boronic acid are compatible in the reaction, affording the corresponding fluoroalkyl ketones in moderate to good yields. Further late-stage di-, and trifluoroacylation of drug molecule clofibrate and estrone demonstrated the synthetic practicability of this protocol.2009 Elsevier Ltd. All rights reserved



中文翻译:

常温下钯催化(杂)芳基硼酸与氟代硫代乙酸酯的氟酰化反应

描述了在环境温度下钯催化的(杂)芳基硼酸与氟代硫代乙酸酯的氟代酰化反应。各种芳基和杂芳基硼酸在反应中是相容的,以中等至良好的产率提供相应的氟代烷基酮。药物分子clofibrate和雌酮的进一步后期二氟和三氟酰化证明了该方案的合成实用性。2009Elsevier Ltd.保留所有权利

更新日期:2020-03-10
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