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Correction to: Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy.
Circulation ( IF 37.8 ) Pub Date : 2020-03-09 , DOI: 10.1161/cir.0000000000000765


In the article by Toepfer et al, “Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy,” which published online ahead-of-print on January 27, 2020, and appeared in the March 10, 2020, issue of the journal (Circulation. 2020;141:828-842. doi: 10.1161/CIRCULATIONAHA.119.042339), a correction is needed.


A correction was made to Figure 3. The original data in panels J and L inadvertently included unpaced iPSC-CMs. The revised panels J and L now show only paced cells. There was no change to the figure lesions.


Additionally, the word ‘non-hydrolyzable’ was removed from the following sentence in the Results section:


“Myosin heads that are in the SRX conformation cycle ATP slowly, whereas free myosin heads in the DRX conformation have 5-fold11 faster ATP turnover (Figure 1A). With the use of a non-hydrolyzable fluorescent ATP analogue, Mant-ATP…”


And it now reads:


“Myosin heads that are in the SRX conformation cycle ATP slowly, whereas free myosin heads in the DRX conformation have 5-fold11 faster ATP turnover (Figure 1A). With the use of a fluorescent ATP analogue, Mant-ATP…”


This deletion relates to unpublished discussions among researchers who theorize there may be partial hydrolysis of this compound. Thus, the authors felt it best to delete the word.


The correction has been made to the current print and online version of the article, which is available at https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.042339.



中文翻译:

校正至:肌球蛋白螯合可调节肌节功能,心肌细胞能量和代谢,从而告知肥厚型心肌病的发病机理。

在Toepfer等人的文章“肌球蛋白固着调节肌节功能,心肌细胞能量代谢和代谢,揭示肥厚性心肌病的发病机理”中,该文章于2020年1月27日在线出版,并于3月10日发表, 2020年,发行期刊(Circulation。2020 ; 141:828-842。doi:10.1161 / CIRCULATIONAHA.119.042339),需要更正。


对图3进行了校正。面板J和L中的原始数据无意中包括了无节奏的iPSC-CM。修改后的面板J和L现在仅显示节奏单元。病变部位无变化。


此外,从“结果”部分的以下句子中删除了“不可水解”一词:


“处于SRX构象的肌球蛋白头部使ATP的循环缓慢,而处于DRX构象的游离肌球蛋白头部的ATP周转速度提高了11倍(图1A)。通过使用不可水解的荧光ATP类似物,Mant-ATP……”


现在显示为:


“处于SRX构象的肌球蛋白头部使ATP的循环缓慢,而处于DRX构象的游离肌球蛋白头部的ATP周转速度提高了11倍(图1A)。使用荧光ATP类似物,Mant-ATP……”


这种删除与研究人员之间未发表的讨论有关,他们认为该化合物可能会部分水解。因此,作者认为最好删除该词。


已对本文的当前印刷版和在线版本进行了更正,该版本可从https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.042339获得。

更新日期:2020-03-10
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