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Synergistic Chemotherapy for Breast Cancer and Breast Cancer Brain Metastases via Paclitaxel-Loaded Oleanolic Acid Nanoparticles.
Molecular Pharmaceutics ( IF 4.9 ) Pub Date : 2020-03-09 , DOI: 10.1021/acs.molpharmaceut.0c00044
Youmei Bao 1 , Shenqi Zhang 2 , Zeming Chen 2 , Ann T Chen 3 , Junning Ma 2 , Gang Deng 2 , Weiguo Xu 4 , Jiangbing Zhou 2, 3 , Zhi-Qiang Yu 1 , Guangyu Yao 5 , Jianjun Chen 1
Affiliation  

Breast cancer is the most common type of cancer in women. About 12% of all women in the United States will be diagnosed with breast cancer over their lifetimes. At the same time, incidences of brain metastases (BMs) are increasing and represent an emerging health threat. However, there is no effective chemotherapy for breast cancer brain metastases (BCBMs), which is largely due to lack of efficient delivery of antitumor drugs or drug combinations to the brain. In this study, oleanolic acid (OA), a natural pentacyclic triterpenoid compound with excellent antitumor activity, was found to form nanoparticles (NPs) and efficiently penetrate the brain for BCBMs treatment. On the basis of these findings, we developed a synergistic combinatorial chemotherapeutic regimen by formulating paclitaxel (PTX) into OA NPs and demonstrated that the resulting PTX-OA NPs effectively inhibited primary breast cancer and BCBMs in mouse xenografts. Collectively, this study introduces a new direction to treat primary breast cancer and BCBMs through noninvasive combination chemotherapy.

中文翻译:

通过紫杉醇负载齐墩果酸纳米颗粒对乳腺癌和乳腺癌脑转移的协同化学疗法。

乳腺癌是女性最常见的癌症类型。在美国,一生中将有大约12%的女性被诊断出患有乳腺癌。同时,脑转移(BMs)的发生率正在增加,并且代表着新出现的健康威胁。但是,目前尚没有针对乳腺癌脑转移瘤(BCBM)的有效化学疗法,这在很大程度上是由于缺乏有效的抗肿瘤药物或药物组合到大脑的传递。在这项研究中,发现齐墩果酸(OA)是一种具有优异抗肿瘤活性的天然五环三萜类化合物,可形成纳米颗粒(NPs)并有效地渗透到大脑中,以治疗BCBMs。根据这些发现,我们通过将紫杉醇(PTX)配制成OA NP,开发了一种协同的联合化疗方案,并证明了所得的PTX-OA NP有效抑制小鼠异种移植物中的原发性乳腺癌和BCBM。总体而言,这项研究为通过无创联合化疗治疗原发性乳腺癌和BCBMs提供了新的方向。
更新日期:2020-04-24
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