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Sulfated and Oxygenated Imidazoline Derivatives: Synthesis, Antioxidant Activity and Light-Mediated Antibacterial Activity.
ChemMedChem ( IF 3.4 ) Pub Date : 2020-04-02 , DOI: 10.1002/cmdc.202000048
Martín S Faillace 1 , Ana P Silva 2 , Antonio L Alves Borges Leal 3 , Luciana Muratori da Costa 3 , Humberto M Barreto 3 , Walter J Peláez 1
Affiliation  

Imidazoline derivatives with different exocyclic substituents were simply prepared from common starting materials. The procedures were carried out in an eco-friendly manner. The antioxidant activity of these derivatives was explored by different experimental assays, such as ABTS.+ and DPPH. scavenging assay, as well as reducing power assay. The structural differences are discussed in terms of the results. Sulfur analogs showed higher antioxidant activity than their oxygenated counterparts. The same tendency was observed in microbiological studies, in which the same imidazoline compounds were assayed for light-mediated activity against of Staphylococcus aureus and Escherichia coli strains. A light-enhanced activity was observed for almost all the sulfated imidazolines after exposure to UV-A (400-320 nm) light.

中文翻译:

硫酸和氧代咪唑啉衍生物:合成,抗氧化活性和光介导的抗菌活性。

具有不同环外取代基的咪唑啉衍生物可以简单地从常见的起始原料制备。该程序以环保的方式进行。这些衍生物的抗氧化活性通过不同的实验测定方法进行了探索,例如ABTS。+和DPPH。清除测定以及降低功率测定。根据结果​​讨论结构差异。含硫类似物显示出比其含氧同类物更高的抗氧化活性。在微生物学研究中观察到了相同的趋势,其中分析了相同的咪唑啉化合物对金黄色葡萄球菌和大肠杆菌菌株的光介导活性。暴露于UV-A(400-320 nm)光后,几乎所有硫酸化的咪唑啉均观察到光增强活性。
更新日期:2020-03-06
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