In the rat pancreas, somatostatin tonically inhibits glucagon secretion and is required for glucose-induced inhibition of glucagon secretion.,Acta Physiologica

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In the rat pancreas, somatostatin tonically inhibits glucagon secretion and is required for glucose-induced inhibition of glucagon secretion.
Acta Physiologica ( IF 6.3 ) Pub Date : 2020-03-07 , DOI: 10.1111/apha.13464
Stella F S Xu _{1,

2} , Daniel B Andersen _{1,

2} , Jose M G Izarzugaza ₃ , Rune E Kuhre _{1,

2} , Jens J Holst _{1,

2}

Affiliation

It is debated whether the inhibition of glucagon secretion by glucose results from direct effects of glucose on the α‐cell (intrinsic regulation) or by paracrine effects exerted by beta‐ or delta‐cell products.

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