Cyclin D1 is a protein encoded by the CCND1 gene, located on 11q13 chromosome, which is a key component of the physiological regulation of the cell cycle. CCND1/cyclin D1 is upregulated in several types of human tumors including melanoma and is currently classified as an oncogene that promotes uncontrolled cell proliferation. Despite the demonstrated importance of CCND1/cyclin D1 as a central oncogene in several types of human tumors, its knowledge in melanoma is still limited. This review examines data published on upregulation of the CCND1 gene and cyclin D1 protein in the melanoma setting, focusing on the pathways and molecular mechanisms involved in the activation of the gene and on the clinical and therapeutic implications.

中文翻译：

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细胞周期蛋白 D1 在黑色素瘤中的影响的更新

Cyclin D1是CCND1基因编码的蛋白质，位于11q13染色体上，是细胞周期生理调控的关键成分。CCND1 /cyclin D1 在包括黑色素瘤在内的几种人类肿瘤中上调，目前被归类为促进不受控制的细胞增殖的致癌基因。尽管CCND1 /cyclin D1 作为几种类型人类肿瘤的中心癌基因已被证明具有重要性，但其对黑色素瘤的了解仍然有限。本综述审查了已发表的关于黑色素瘤环境中CCND1基因和细胞周期蛋白 D1 蛋白上调的数据，重点关注参与基因激活的途径和分子机制以及临床和治疗意义。