Purines and pyrimidines are essential nutrients for any cell. Most organisms are able to synthesize their own purines and pyrimidines, but this ability was lost in protozoans that adapted to parasitism, leading to a great diversification in transporter activities in these organisms, especially for the acquisition of amino acids and nucleosides from their hosts throughout their life cycles. Many of these transporters have been shown to have sufficiently different substrate affinities from mammalian transporters, making them good carriers for therapeutic agents. In this review, we summarize the knowledge obtained on purine and pyrimidine activities identified in protozoan parasites to date and discuss their importance for the survival of these parasites and as drug carriers, as well as the perspectives of developments in the field.

中文翻译：

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致病性原生动物的嘌呤和嘧啶转运蛋白 - 治疗剂的管道。

嘌呤和嘧啶是任何细胞必不可少的营养素。大多数生物都能够合成自己的嘌呤和嘧啶，但是这种能力在适应寄生的原生动物中丧失了，导致这些生物的转运蛋白活动发生了很大的变化，特别是在整个过程中从宿主那里获得氨基酸和核苷。生命周期。许多这些转运蛋白已被证明与哺乳动物转运蛋白具有足够不同的底物亲和力，使它们成为治疗剂的良好载体。在这篇综述中，我们总结了迄今为止在原生动物寄生虫中鉴定的嘌呤和嘧啶活性的知识，并讨论了它们对这些寄生虫的生存和作为药物载体的重要性，以及该领域的发展前景。