A protein Pascal triangle has been constructed as new type of supramolecular architecture by using the inducing ligand strategy that we previously developed for protein assemblies. Although mathematical studies on this famous geometry have a long history, no work on such Pascal triangles fabricated from native proteins has been reported so far due to their structural complexity. In this work, by carefully tuning the specific interactions between the native protein building block WGA and the inducing ligand R‐SL , a 2D Pascal‐triangle lattice with three types of triangular voids has been assembled. Moreover, a 3D crystal structure was obtained based on the 2D Pascal triangles. The distinctive carbohydrate binding sites of WGA and the intralayer as well as interlayer dimerization of RhB was the key to facilitate nanofabrication in solution. This strategy may be applied to prepare and explore various sophisticated assemblies based on native proteins.

中文翻译：

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通过诱导配体策略制造蛋白质的帕斯卡三角格子。

通过使用我们先前为蛋白质组装体开发的诱导配体策略，已将蛋白质Pascal三角形构建为新型的超分子结构。尽管对这种著名几何学的数学研究已有很长的历史，但由于其结构复杂性，迄今为止尚无关于用天然蛋白质制成的帕斯卡三角形的报道。在这项工作中，通过仔细调节天然蛋白质构件WGA和诱导配体R‐SL之间的特定相互作用，已组装了具有三种类型的三角形空隙的2D Pascal三角形晶格。此外，基于2D帕斯卡三角形获得了3D晶体结构。WGA和RhB的内层以及层间二聚化的独特碳水化合物结合位点是促进溶液中纳米加工的关键。该策略可用于基于天然蛋白质制备和探索各种复杂的组装。