We present an ultrafast approach for the synthesis of 2-(benzhydrylthio)benzo[d]oxazole, an antimalarial drug, in 75% yield from benzo[d]oxazole-2-thiol and benzhydryl bromide via an unstable lithium thiolate intermediate in the presence of n-BuLi. The precisely controlled two-step reaction at room temperature in a simple capillary microreactor enables a drastic decrease of the synthesis time to milliseconds (580 ms) from 10 min in a flask. Furthermore, a simple continuous-flow operation of the low cost reactor readily realizes a high throughput, leading to a several gram scale production (approximately 4 g per 13.3 min) at a very high flow rate of 7.6 ml min⁻¹.

中文翻译：

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通过毛细管微反应器中不稳定的硫醇锂中间体超快速合成抗疟药2-（苯甲硫基）苯并[d]恶唑

我们提出了一种通过存在下的不稳定的硫醇锂中间体从苯并[ d ]恶唑-2-硫醇和苄基溴化物以75％的产率合成抗疟药2-（苯甲硫基）苯并[ d ]恶唑的超快方法。的n -BuLi。在简单的毛细管微反应器中，在室温下进行精确控制的两步反应可将合成时间从烧瓶中的10分钟急剧减少至毫秒（580 ms）。此外，低成本反应器的简单连续流操作容易实现高产量，从而以7.6 ml min ^-1的非常高的流速导致几克规模的产量（每13.3分钟约4 g）。