Marine seaweed polysaccharides have been considered as a potential resource for antiallergic therapy. Alginate is an acidic linear polysaccharide and soluble dietary fiber that was extracted from brown algae, Laminaria japonica. The molecular weight of alginate was 108 kDa, and its water solution exhibited non-Newtonian characteristics, including viscoelasticity and shear-thinning behavior. The ability of alginate to inhibit allergic reactions was investigated in ovalbumin (OVA)-induced BALB/c mice, which have been widely used as a mouse model of egg allergy. The results showed that alginate could effectively attenuate the occurrence of allergic reactions, including improving the integrity of the intestinal epithelial villi and inhibition of mast cell degranulation in the jejunum, in OVA-induced mice. Moreover, after treatment with alginate, the levels of IgE, histamine and IL-4 in OVA-induced mice were remarkably decreased, and the levels of IFN-γ were markedly increased. In addition, the number of Treg cells in spleen tissues in OVA-induced mice was increased by alginate, and the OVA-induced differentiation of Th0 cells into Th2 cells was significantly inhibited. These results demonstrate that alginate possesses potential antiallergic activities in a mouse model of egg allergy, which might provide important evidence that alginate, extracted from Laminaria japonica, can be developed into a novel functional food for inhibiting egg allergy.

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海藻酸盐在卵清蛋白诱导的小鼠模型中对变态反应的抑制活性

海洋海藻多糖被认为是抗过敏疗法的潜在资源。海藻酸盐是一种酸性线性多糖和可溶性膳食纤维，是从褐藻，海带中提取的。海藻酸盐的分子量为108 kDa，其水溶液具有非牛顿特性，包括粘弹性和剪切稀化行为。在卵白蛋白（OVA）诱导的BALB / c小鼠中研究了藻酸盐抑制过敏反应的能力，该小鼠已广泛用作卵变态反应的小鼠模型。结果表明，在OVA诱导的小鼠中，藻酸盐可有效减轻过敏反应的发生，包括改善肠上皮绒毛的完整性和抑制空肠肥大细胞脱粒。此外，用藻酸盐处理后，OVA诱导的小鼠中的IgE，组胺和IL-4的水平显着降低，而IFN-γ的水平显着升高。此外，海藻酸盐可增加OVA诱导的小鼠脾脏组织中Treg细胞的数量，并显着抑制OVA诱导的Th0细胞向Th2细胞的分化。这些结果表明，藻酸盐在鸡蛋过敏的小鼠模型中具有潜在的抗过敏活性，这可能提供重要的证据表明从藻类中提取的藻酸盐日本海带可以发展成为一种新型的抑制鸡蛋过敏的功能性食品。