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Sulfur dioxide signaling molecule-responsive polymeric nanoparticles
Biomaterials Science ( IF 6.6 ) Pub Date : 2020-03-09 , DOI: 10.1039/d0bm00276c
Ruru Li 1, 2, 3, 4, 5 , Xiaoyu Huang 1, 2, 3, 4, 5 , Guolin Lu 1, 2, 3, 4, 5 , Chun Feng 1, 2, 3, 4, 5
Affiliation  

Stimuli-responsive polymer nano-capsules toward a specific signaling molecule show great potential in the fabrication of smart and efficient controlled/targeted drug vehicles. Herein, we design and synthesize a PEG45-b-PVPOP14 diblock copolymer (PEG = poly(ethylene glycol) and PVPOP = poly(4-vinylphenyl 4-oxopentanoate), the subscripts representing the number of repeat units of each block) with levulinate-protected phenol side groups. The PEG45-b-PVPOP14 diblock copolymer could self-assemble to form large compound micelles in aqueous media. Since the core of the large compound micelles formed contains both hydrophilic PEG and hydrophobic PVPOP domains, this kind of micelle is able to load both hydrophobic and hydrophilic species within the core. The ester moiety of levulinate-protected phenol can be selectively cleaved upon incubation with a sulfite, a derivative of SO2 in aqueous media, to give phenol groups. Thus, the sulfite exhibits the ability to alter the amphiphilicity and further the self-assembled behavior of PEG45-b-PVPOP14. The release of payloads in the core of micelles can be accelerated by triggering of the sulfite. Significantly, the nano-capsule of PEG45-b-PVPOP14 shows specific response to the sulfite (SO2) with slight interference of other bio-species, such as Cys, GSH and Hcy. As far as we are aware, this is the first example of a nano-capsule with sulfite (SO2) specific responsiveness. We envisage that this polymer model could broaden the scope of biological signaling molecule responsive macromolecular systems and provide a new platform to fabricate SO2-responsive biomedicine materials.

中文翻译:

二氧化硫信号分子响应型聚合物纳米颗粒

对特定信号分子的刺激响应性聚合物纳米胶囊在制造智能,有效的受控/靶向药物载体中显示出巨大潜力。本文中,我们设计并合成了PEG 45 - b -PVPOP 14双嵌段共聚物(PEG =聚乙二醇和PVPOP =聚4-乙烯基苯基4-氧戊酸酯),下标表示每个嵌段的重复单元数乙酰丙酸酯保护的苯酚侧基。PEG 45 - b -PVPOP 14二嵌段共聚物可以在水性介质中自组装形成较大的胶束。由于形成的大化合物胶束的核心同时包含亲水性PEG和疏水性PVPOP结构域,因此这种胶束能够将疏水性和亲水性物质同时加载到核心中。通过与亚硫酸盐(SO 2的衍生物在水性介质中)孵育,乙酰丙酸酯保护的苯酚的酯部分可以选择性地裂解,得到苯酚基团。因此,亚硫酸盐表现出改变两亲性的能力,并进一步改变了PEG 45 - b -PVPOP 14的自组装行为。通过触发亚硫酸盐可以加速胶束核心中有效负载的释放。值得注意的是,PEG 45的纳米胶囊- b -PVPOP 14示出了特定的响应于该亚硫酸盐(SO 2)与其他生物物质,如半胱氨酸,谷胱甘肽和半胱氨酸的轻微的干扰。据我们所知,这是具有亚硫酸盐(SO 2)特异性响应能力的纳米胶囊的第一个例子。我们设想,该聚合物模型可以拓宽生物信号分子响应性大分子系统的范围,并为制造SO 2响应性生物医学材料提供一个新的平台。
更新日期:2020-04-24
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