Asymmetric total synthesis of two naturally occurring α,β-enone containing RALs, L-783290 and L-783277 is described in this article. An E-selective Horner–Wadsworth–Emmons (HWE) olefination was used as a key reaction to construct the C_7′–C_8′ olefinic unsaturation in L-783290. An enantiopure alkyne addition to the aldehyde followed by Z-selective partial reduction was employed to construct the C_7′–C_8′ olefinic unsaturation in L-783277. Biomimetic lactonization reaction was used to construct the macrolactone core in both the target molecules.

中文翻译：

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天然存在的含α，β-烯酮的RAL，L-783290和L-783277的不对称总合成，通过分子内碱基介导的大内酯化反应

本文描述了两种天然存在的含α，β-烯酮的RALs L-783290和L-783277的不对称全合成。一个Ë -选择性-沃兹沃思-埃蒙斯霍纳（HWE）烯用作键反应来构建Ç _7' -C _8'的烯属不饱和度在L-783290。的对映体纯炔除醛随后Ž -选择性部分还原是用于构造与c _7' -C _8'的烯属不饱和度在L-783277。仿生内酯化反应用于在两个靶分子中构建大内酯核。