Objective

To evaluate associations between maternal antidepressant use during pregnancy and hypoglycemia in term neonates.

Study design

We conducted a prospective comparative cohort study of neonates of ≥37 weeks’ gestation. Neonates whose mothers used antidepressants during pregnancy were compared with randomly selected cohort of neonates whose mothers did not use antidepressants. Blood glucose was measured at 24 ± 2 h after birth. Hypoglycemia was defined as blood glucose level <2.6 mmol/L. We needed 60 patients in each group to reject the null hypothesis.

Results

Mean gestational ages were 39 vs. 40 weeks (p < 0.01) and birthweights were 3250 vs. 3360 g (p = 0.08) for antidepressant-exposed vs. -unexposed neonates. There were no significant differences between groups in odds of hypoglycemia (4/59: exposed vs. 2/61: unexposed; adjusted relative risk 1.73; 95% confidence interval [CI] 0.37–8.92) or mean blood glucose levels.

Conclusions

Maternal antidepressant use during pregnancy was not associated with neonatal hypoglycemia at 24 h of age.

中文翻译：

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怀孕期间母亲抗抑郁药的使用和新生儿低血糖：前瞻性队列研究。

客观的

评估妊娠期间母亲使用抗抑郁药与足月新生儿低血糖之间的关联。

学习规划

我们对 ≥ 37 周妊娠的新生儿进行了前瞻性比较队列研究。将母亲在怀孕期间使用抗抑郁药的新生儿与随机选择的母亲未使用抗抑郁药的新生儿队列进行比较。在出生后 24±2 小时测量血糖。低血糖定义为血糖水平<2.6 mmol/L。我们需要每组 60 名患者来拒绝零假设。

结果

平均胎龄为 39 周 vs. 40 周 ( p  < 0.01)，出生体重分别为 3250 和 3360 g ( p  = 0.08)，分别是暴露于抗抑郁药的新生儿与未暴露的新生儿。低血糖几率（4/59：暴露 vs. 2/61：未暴露；调整后的相对风险 1.73；95% 置信区间 [CI] 0.37-8.92）或平均血糖水平在各组之间没有显着差异。

结论

母亲在怀孕期间使用抗抑郁药与 24 小时时的新生儿低血糖无关。