Jamming models developed in inanimate matter have been widely used to describe cell packing in tissues^{1,2,3,4,5,6,7}, but predominantly neglect cell diversity, despite its prevalence in biology. Most tissues, animal brains in particular, comprise a mix of many cell types, with mounting evidence suggesting that neurons can recognize their respective types as they organize in space^8,9,10,11. How cell diversity revises the current jamming paradigm is unknown. Here, in the brain of the flatworm planarian Schmidtea mediterranea, which exhibits remarkable tissue plasticity within a simple, quantifiable nervous system^{12,13,14,15,16}, we identify a distinct packing state, ‘chromatic’ jamming. Combining experiments with computational modelling, we show that neurons of distinct types form independent percolating networks barring any physical contact. This jammed state emerges as cell packing configurations become constrained by cell type-specific interactions and therefore may extend to describe cell packing in similarly complex tissues composed of multiple cell types.

在无生命物质中开发的干扰模型已被广泛用于描述组织中的细胞堆积^{1,2,3,4,5,6,7}，但主要忽略了细胞多样性，尽管它在生物学中很普遍。大多数组织，尤其是动物大脑，由多种细胞类型混合而成，越来越多的证据表明，神经元在空间中组织时可以识别它们各自的类型^8,9,10,11。细胞多样性如何修改当前的干扰范式尚不清楚。在这里，在扁虫涡虫Schmidtea mediterranea的大脑中，它在一个简单的、可量化的神经系统中表现出显着的组织可塑性^{12,13,14,15,16}，我们确定了一种独特的包装状态，即“彩色”干扰。将实验与计算建模相结合，我们表明不同类型的神经元形成独立的渗透网络，禁止任何物理接触。当细胞堆积配置受到细胞类型特异性相互作用的限制时，这种阻塞状态就会出现，因此可以扩展到描述由多种细胞类型组成的类似复杂组织中的细胞堆积。