Individuals with radiologically isolated syndrome (RIS) have incidental magnetic resonance imaging (MRI) abnormalities suggestive of multiple sclerosis (MS).¹ Recent studies using susceptibility-based imaging have shown that a subgroup of chronic MS white matter lesions (WMLs) have a rim of paramagnetic susceptibility-associated signal loss at the lesion edge, the paramagnetic rim sign (PRS), that is associated with the presence of iron inside phagocytes, which indicates chronic, active demyelination.^2,3 The objective of this study was to determine whether patients with RIS have WMLs that are positive for PRS (PRS+).

中文翻译：

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顺磁框签在放射学上被隔绝的综合症状。

患有放射孤立综合征（RIS）的个体具有偶发性磁共振成像（MRI）异常，提示多发性硬化症（MS）。¹最近使用基于药敏性成像的研究表明，慢性MS白质病变（WML）的亚组在病灶边缘具有与顺磁药敏性相关的信号丢失边缘，即与药物相关的顺磁药丸标志（PRS）。吞噬细胞中铁的存在，表明慢性活跃的脱髓鞘。^{2 ，3}的目标本研究的是确定患者是否RIS具有用于PRS（PRS +）正WMLs。