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Insight into the expression of toll-like receptors 2 and 4 in patients with abdominal aortic aneurysm.
Molecular Biology Reports ( IF 2.8 ) Pub Date : 2020-03-07 , DOI: 10.1007/s11033-020-05366-x
Agnieszka Jabłońska 1, 2 , Christoph Neumayer 2 , Michael Bolliger 2 , Christopher Burghuber 2 , Markus Klinger 2 , Svitlana Demyanets 3 , Josif Nanobachvili 2 , Ihor Huk 2
Affiliation  

An abdominal aortic aneurysm (AAA) is a relatively common, life-threatening disease prevalent in persons over the age of 65. In recent years, an increasing number of studies have suggested that pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs), may serve as important regulators in the development of AAAs. In this study, we evaluated the TLR2 and TLR4 expression in the aortic wall and blood of patients with AAA. The TLR2 and TLR4 mRNA expression were significantly higher in the blood of patients with AAA than in the blood of healthy volunteers (p = 0.009 and p = 0.010, respectively). The expression of TLR2 and TLR4 transcripts was also higher in the blood compared with the aortic wall tissue of AAA patients (p = 0.001 for both). Higher TLR2 protein expression was observed in the aortic wall of AAA patients compared with the blood (p = 0.026). A significantly higher concentration of TNF-α and IL-4 in patients with AAA than in healthy volunteers (p < 0.001 for both) was noticed. This study suggests that TLR2 may play a role in the inflammatory response in the aorta, both locally and systemically, in patients with AAA.

中文翻译:

了解腹主动脉瘤患者Toll样受体2和4的表达。

腹主动脉瘤(AAA)是一种相对常见的威胁生命的疾病,普遍存在于65岁以上的人群中。近年来,越来越多的研究表明,模式识别受体(PRR)包括Toll样受体(TLR),可能会成为AAA发展中的重要监管者。在这项研究中,我们评估了AAA患者的主动脉壁和血液中TLR2和TLR4的表达。AAA患者的血液中TLR2和TLR4 mRNA的表达显着高于健康志愿者的血液(分别为p = 0.009和p = 0.010)。与AAA患者的主动脉壁组织相比,血液中TLR2和TLR4转录物的表达也更高(两者均为p = 0.001)。与血液相比,在AAA患者的主动脉壁中观察到了更高的TLR2蛋白表达(p = 0.026)。注意到AAA患者中TNF-α和IL-4的浓度明显高于健康志愿者(两者均p <0.001)。这项研究表明,在AAA患者中,TLR2可能在局部和全身性的主动脉炎性反应中起作用。
更新日期:2020-03-09
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