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Platelet mtDNA content and leukocyte count influence whole blood mtDNA content
Mitochondrion ( IF 4.4 ) Pub Date : 2020-05-01 , DOI: 10.1016/j.mito.2020.03.001
Hanjoo B Shim 1 , Omair Arshad 2 , Izabella Gadawska 3 , Hélène C F Côté 4 , Anthony Y Y Hsieh 2
Affiliation  

Changes in whole blood (WB) mitochondrial DNA (mtDNA) content are associated with health and disease. Platelet-derived mtDNA can confound WB mtDNA content measurements. From a sample of 44 volunteers, we show that platelet mtDNA content and platelet:leukocyte ratio are both dependent predictors of WB mtDNA content, but that platelet count itself is not. Furthermore, when platelet:leukocyte ratio increased by <2-fold ex vivo, the effect on WB mtDNA content was minimal. Altogether, this study clarifies the contribution of platelet mtDNA content rather than platelet count on WB mtDNA content measurements, and identifies defined parameters for future research on WB mtDNA content.

中文翻译:

血小板mtDNA含量和白细胞计数影响全血mtDNA含量

全血 (WB) 线粒体 DNA (mtDNA) 含量的变化与健康和疾病有关。血小板衍生的 mtDNA 会混淆 WB mtDNA 含量测量。从 44 名志愿者的样本中,我们表明血小板 mtDNA 含量和血小板:白细胞比率都是 WB mtDNA 含量的依赖预测因子,但血小板计数本身不是。此外,当血小板:白细胞比例在体外增加 <2 倍时,对 WB mtDNA 含量的影响很小。总之,这项研究阐明了血小板 mtDNA 含量而不是血小板计数对 WB mtDNA 含量测量的贡献,并确定了未来 WB mtDNA 含量研究的定义参数。
更新日期:2020-05-01
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