Stressor-Cortisol Concordance Among Individuals at Clinical High-Risk for Psychosis: Novel Findings from the NAPLS Cohort,Psychoneuroendocrinology

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Stressor-Cortisol Concordance Among Individuals at Clinical High-Risk for Psychosis: Novel Findings from the NAPLS Cohort
Psychoneuroendocrinology ( IF 3.7 ) Pub Date : 2020-05-01 , DOI: 10.1016/j.psyneuen.2020.104649
Alexis E Cullen ₁ , Jean Addington ₂ , Carrie E Bearden ₃ , William S Stone ₄ , Larry J Seidman ₄ , Kristin S Cadenhead ₅ , Tyrone D Cannon ₆ , Barbara A Cornblatt ₇ , Daniel H Mathalon ₈ , Thomas H McGlashan ₉ , Diana O Perkins ₁₀ , Ming T Tsuang ₅ , Scott W Woods ₉ , Elaine F Walker ₁₁

Affiliation

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada.
Department of Psychiatry and Behavioural Sciences and Psychology, UCLA, Los Angeles, United States.
Harvard Medical School, Departments of Psychiatry at Massachusetts Mental Health Center Public Psychiatry Division, Beth Israel Deaconess Medical Center, Massachusetts, General Hospital, Boston, MA, United States.
Department of Psychiatry, University of California, San Diego, CA, United States.
Department of Psychiatry, Yale University, New Haven, Connecticut, United States.
Department of Psychiatry, Zucker Hillside Hospital, Long Island, NY, United States.
Department of Psychiatry, University of California, San Francisco Veterans Affairs Medical Center, San Francisco, CA, United States.
Department of Psychiatry, Yale University, New Haven, CT, United States.
Department of Psychiatry, University of North Carolina, Chapel Hill, NC, United States.
Department of Psychology, Emory University, Atlanta, GA, United States; Department of Psychiatry, Emory University, Atlanta, GA, United States.

Highlights • CHR youth showed greater psychosocial stressor exposure and distress than controls.• Only CHR youth who later developed psychosis had higher basal cortisol at baseline.• Pooled stressor-cortisol concordance values were highest in CHR converters.• The degree of concordance distinguished CHR converters from CHR non-converters.• Concordance in controls was intermediate to CHR converters and non-converters.

中文翻译：

临床精神病高危个体的压力-皮质醇一致性：来自 NAPLS 队列的新发现

亮点 • CHR 青年表现出比对照组更多的心理社会压力源暴露和痛苦。• 只有后来发展为精神病的 CHR 青年在基线时具有更高的基础皮质醇。• CHR 转换器中的合并压力源-皮质醇一致性值最高。• 一致性程度区分了 CHR 转换器来自 CHR 非转化者。• 控制的一致性介于 CHR 转化者和非转化者之间。

更新日期：2020-05-01

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