BACKGROUND Recent studies revealed that several genetic polymorphisms of haptoglobin gene (HP) and the haptoglobin-related protein gene (HPR) associated not only with haptoglobin (HP) but total, non-HDL, and/or LDL cholesterol concentrations in various populations. METHODS Association between serum HP concentrations and polymorphisms of HP and the HPR gene, or anthropometric and metabolic factors were examined in Mongolian participants (n = 927) using linear regression analyses. RESULTS The association of HP and HPR polymorphisms with serum HP concentration but not serum lipids concentrations was observed. However, subgroup analysis revealed that the association of HP and HPR polymorphisms with serum HP concentration was weakened in subgroup of obese (BMI ≥ 30) subjects and positive correlations between serum HP and non-HDL cholesterol, HDL cholesterol or triglyceride concentrations were observed in the obese subjects as compared with in subgroups of normal weight (BMI < 25) and overweight (25 ≤ BMI < 30) subjects. CONCLUSION The degree of obesity strongly affects the relationships between serum HP concentrations and several genetic, anthropometric and metabolic factors. These results suggested that we need to take into account the degree of obesity when considering the HP polymorphisms as predictive markers for clinical states.

中文翻译：

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在肥胖的蒙古族人群中血清触珠蛋白与胆固醇和甘油三酸酯浓度呈正相关。

背景技术最近的研究表明，触珠蛋白基因（HP）和触珠蛋白相关蛋白基因（HPR）的几种遗传多态性不仅与触珠蛋白（HP）有关，而且与各个人群的总，非HDL和/或LDL胆固醇浓度有关。方法采用线性回归分析，对蒙古族参与者（n = 927）的血清HP浓度与HP和HPR基因多态性或人体测量和代谢因子之间的关联进行了研究。结果观察到HP和HPR多态性与血清HP浓度相关，但与血脂水平无关。但是，亚组分析显示，肥胖（BMI≥30）受试者亚组中HP和HPR多态性与血清HP浓度的相关性减弱，并且血清HP与非HDL胆固醇之间呈正相关，与正常体重（BMI <25）和超重（25≤BMI <30）受试者的亚组相比，肥胖受试者的HDL胆固醇或甘油三酯浓度较高。结论肥胖程度强烈影响血清HP浓度与几种遗传，人体测量和代谢因素之间的关系。这些结果表明，在将HP多态性视为临床状态的预测指标时，我们需要考虑肥胖程度。