Supplemental Digital Content is available in the text. Blood pressure (BP) control rates among US adults taking antihypertensive medication have not increased over the past decade. Many adults require 2 or more classes of antihypertensive medication to achieve guideline-recommended BP goals, but the proportion of US adults taking antihypertensive medication monotherapy, versus combination therapy, has not been quantified using contemporary data. We analyzed data from 2005 to 2008, 2009 to 2012, and 2013 to 2016 National Health and Nutrition Examination Surveys to determine trends in monotherapy and combinations of antihypertensive medication classes among US adults age ≥20 years with hypertension taking antihypertensive medication (n=7837). The proportion of US adults taking antihypertensive medication with uncontrolled BP (ie, systolic BP ≥140 or diastolic BP ≥90 mm Hg) was 32.3%, 30.2%, and 31.0% in 2005 to 2008, 2009 to 2012, and 2013 to 2016, respectively (Ptrend=0.37). Between 2005 to 2008 and 2013 to 2016, there was no evidence of changes in the proportions of US adults taking antihypertensive monotherapy (39.5%–40.4%, Ptrend=0.67), dual-therapy (37.9%–38.3%, Ptrend=0.75), triple-therapy (17.6%–16.5%, Ptrend=0.36), or quadruple-therapy (4.4%–4.3%, Ptrend=0.93). Between 2005 to 2008 and 2013 to 2016, there was no evidence of changes in the proportions of US adults with uncontrolled BP taking antihypertensive monotherapy (39.3%–40.6%, Ptrend=0.78). A high proportion of US adults with hypertension, including those with uncontrolled BP, are taking one antihypertensive medication class. Increasing the use of dual- and triple-therapy antihypertensive medication regimens may restore the upward trend in BP control rates among US adults.

中文翻译：

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美国成年人抗高血压药物单一疗法和联合用药的趋势，2005-2016 年全国健康和营养检查调查

补充数字内容在文本中可用。在过去十年中，服用抗高血压药物的美国成年人的血压 (BP) 控制率没有增加。许多成年人需要 2 类或更多类抗高血压药物才能达到指南推荐的血压目标，但美国成年人服用抗高血压药物单药治疗与联合治疗的比例尚未使用当代数据进行量化。我们分析了 2005 年至 2008 年、2009 年至 2012 年以及 2013 年至 2016 年的全国健康和营养检查调查的数据，以确定 20 岁以上患有高血压并服用抗高血压药物的美国成年人（n=7837）中单药治疗和抗高血压药物类别组合的趋势. 服用抗高血压药物且血压不受控制的美国成年人的比例（即，2005-2008、2009-2012和2013-2016年收缩压≥140或舒张压≥90 mm Hg）分别为32.3%、30.2%和31.0%（Ptrend=0.37）。2005 年至 2008 年和 2013 年至 2016 年期间，没有证据表明美国成年人服用降压药单药治疗（39.5%–40.4%，Ptrend=0.67）、双联治疗（37.9%–38.3%，Ptrend=0.75）的比例发生变化、三联疗法（17.6%–16.5%，Ptrend=0.36）或四联疗法（4.4%–4.3%，Ptrend=0.93）。在 2005 年至 2008 年和 2013 年至 2016 年之间，没有证据表明美国血压不受控制的成年人服用抗高血压单药治疗的比例发生变化（39.3%–40.6%，Ptrend=0.78）。很大一部分患有高血压的美国成年人，包括那些血压不受控制的人，正在服用一种抗高血压药物。