Supplemental Digital Content is available in the text. Fibromuscular dysplasia (FMD), regarded as a generalized vascular disease, may affect all vascular beds and may result in arterial stenosis, occlusion, aneurysm, or dissection. It has been proposed to systematically evaluate all vascular beds in patients with FMD, regardless of initial FMD involvement. However, the impact of this approach on clinical decisions and on management is unknown. Within the prospective ARCADIA-POL study (Assessment of Renal and Cervical Artery Dysplasia–Poland), we evaluated 232 patients with FMD lesions confirmed in at least one vascular bed, out of 343 patients included in the registry. All patients underwent a detailed clinical evaluation including computed tomography angiography of intracranial and cervical arteries, as well as computed tomography angiography of the abdominal aorta, its branches, and upper and lower extremity arteries. In the study group, FMD lesions were most frequently found in renal arteries (87.5%). FMD was also found in cerebrovascular (24.6%), mesenteric (13.8%), and upper (3.0%) and lower extremity (9.9 %) arteries. Newly diagnosed FMD lesions were found in 34.1% of the patients, and previously undetected vascular complications were found in 25% of the patients. Among all FMD patients included in the study, one out of every 4 evaluated patients qualified for interventional treatment due to newly diagnosed FMD lesions or vascular complications. The ARCADIA-POL study shows for the first time that the systematic and multidisciplinary evaluation of patients with FMD based on a whole-body computed tomography angiography scan has an impact on their clinical management. This proved the necessity of the systematic evaluation of all vascular beds in patients with FMD, regardless of initial FMD involvement.

中文翻译：

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纤维肌肉发育不良患者的系统和多学科评估揭示了以前未发现的纤维肌肉发育不良病变的高患病率并影响临床决策

补充数字内容在文本中可用。纤维肌肉发育不良（FMD）被认为是一种全身血管疾病，可影响所有血管床，并可能导致动脉狭窄、闭塞、动脉瘤或夹层。已提议系统地评估 FMD 患者的所有血管床，无论最初是否受累。然而，这种方法对临床决策和管理的影响尚不清楚。在前瞻性 ARCADIA-POL 研究（肾和颈动脉发育不良的评估 - 波兰）中，我们评估了 232 名至少在一个血管床中确诊的 FMD 病变患者，其中 343 名患者包括在登记册中。所有患者都接受了详细的临床评估，包括颅内和颈动脉的计算机断层扫描血管造影，以及腹主动脉、其分支和上下肢动脉的计算机断层扫描血管造影。在研究组中，FMD 病变最常见于肾动脉（87.5%）。在脑血管 (24.6%)、肠系膜 (13.8%)、上肢 (3.0%) 和下肢 (9.9%) 动脉中也发现了 FMD。在 34.1% 的患者中发现了新诊断的 FMD 病变，在 25% 的患者中发现了先前未发现的血管并发症。在纳入研究的所有 FMD 患者中，每 4 名接受评估的患者中就有 1 名因新诊断的 FMD 病变或血管并发症而有资格接受介入治疗。ARCADIA-POL 研究首次表明，基于全身计算机断层扫描血管造影对 FMD 患者进行的系统和多学科评估对其临床管理产生影响。这证明有必要对 FMD 患者的所有血管床进行系统评估，无论最初是否受累。