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Self-Propelled PLGA Micromotor with Chemotactic Response to Inflammation.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-03-06 , DOI: 10.1002/adhm.201901710
Jiamian Wang 1 , B Jelle Toebes 2 , Adelina S Plachokova 3 , Qian Liu 1 , Dongmei Deng 4 , John A Jansen 1 , Fang Yang 1 , Daniela A Wilson 2
Affiliation  

Local drug delivery systems have recently been developed for multiple diseases that have the requirements of site‐specific actions, prolonged delivery periods, and decreased drug dosage to reduce undesirable side effects. The challenge for such systems is to achieve directional and precise delivery in inaccessible narrow lesions, such as periodontal pockets or root canals in deeper portions of the dentinal tubules. The primary strategy to tackle this challenge is fabricating a smart tracking delivery system. Here, drug‐loaded biodegradable micromotors showing self‐propelled directional movement along a hydrogen peroxide concentration gradient produced by phorbol esters‐stimulated macrophages are reported. The drug‐loaded poly(lactic‐co‐glycolic acid) micromotors with asymmetric coverage of enzyme (patch‐like enzyme distribution) are prepared by electrospraying and postfunctionalized with catalase via 1‐ethyl‐3‐(3‐dimethylaminopropyl) carbodiimide coupling. Doxycycline, a common drug for the treatment of periodontal disease, is selected as a model drug, and the release study by high‐performance liquid chromatography is shown that both the postfunctionalization step and the presence of hydrogen peroxide have no negative influence on drug release profiles. The movement behavior in the presence of hydrogen peroxide is confirmed by nanoparticle tracking analysis. An in vitro model is designed and confirmed the response efficiency and directional control of the micromotors toward phorbol esters‐stimulated macrophages.

中文翻译:

具有对炎症的趋化性反应的自行式PLGA微电机。

最近,针对多种疾病开发了局部药物输送系统,这些疾病需要采取针对特定地点的措施,延长输送时间并减少药物剂量以减少不良副作用。这种系统的挑战是在难以接近的狭窄病变中实现方向性和精确的递送,例如在牙本质小管较深部分的牙周袋或根管。解决这一挑战的主要策略是构建智能跟踪交付系统。在这里,报道了载药的可生物降解的微型电动机,其沿着由佛波酯刺激的巨噬细胞产生的过氧化氢浓度梯度表现出自我推动的方向性运动。通过电喷雾制备具有不对称覆盖酶(类似补丁的酶分布)的载药聚(乳酸-乙醇酸)微电机,并通过1-乙基-3-(3-二甲基氨基丙基)碳二亚胺偶联用过氧化氢酶进行后功能化。选择用于治疗牙周疾病的常用药物强力霉素作为模型药物,通过高效液相色谱法进行的释放研究表明,功能化后步骤和过氧化氢的存在均对药物释放曲线没有负面影响。通过纳米颗粒跟踪分析证实了在过氧化氢存在下的运动行为。设计了一个体外模型,并证实了微电机对佛波酯刺激的巨噬细胞的响应效率和方向控制。
更新日期:2020-04-08
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