In right‐handed patients with Parkinson's disease (PD) or isolated rapid eye movement sleep behavior disorder, dopamine transporter (DAT) [(123)I]β‐carboxymethyoxy‐3‐β‐(4‐iodophenyl) tropane single photon emission computed tomography (SPECT) shows predominant nigrostriatal deficit in the left striatum. This suggests that in PD patients, the nigrostriatal system of the dominant hemisphere is more susceptible to disease‐related dysfunction. To confirm this hypothesis, we investigated whether the nigrostriatal function is symmetric in healthy controls and in patients with PD.

中文翻译：

---

健康受试者黑质纹状体多巴胺能功能缺乏不对称性

在患有帕金森病 (PD) 或孤立性快速眼动睡眠行为障碍的右利手患者中，多巴胺转运蛋白 (DAT) [(123)I]β-羧甲氧基-3-β-(4-碘苯基) 托烷单光子发射计算机断层扫描(SPECT) 显示左侧纹状体中主要的黑质纹状体缺陷。这表明在 PD 患者中，优势半球的黑质纹状体系统更容易受到疾病相关功能障碍的影响。为了证实这一假设，我们调查了健康对照组和 PD 患者的黑质纹状体功能是否对称。