Pyridoxal 5′‐phosphate (PLP) is an organic cofactor employed by ~ 4% of enzymes. The structure of the PLP cofactor allows for the stabilization of carbanions through resonance. A small number of PLP‐dependent enzymes employ molecular oxygen as a cosubstrate. Here, we review the biological roles and possible mechanisms of these enzymes, and we observe that these enzymes are found in multiple protein families, suggesting that reaction with oxygen might have emerged de novo in several protein families and thus could be directed to emerge again through laboratory evolution experiments.

中文翻译：

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氧和吡ido醛磷酸盐依赖性反应的出现

吡rid醛5'-磷酸（PLP）是约4％的酶使用的有机辅因子。PLP辅因子的结构允许通过共振稳定碳负离子。少数PLP依赖性酶利用分子氧作为共底物。在这里，我们审查了这些酶的生物学作用和可能的机制，我们观察到这些酶存在于多个蛋白质家族中，这表明与氧气的反应可能从头出现在几个蛋白质家族中，因此可以通过实验室进化实验。