A Michael addition-driven four-component reaction (4-CR) was developed for derivatizing chromones by strategically suppressing competing 4-CR Ugi reaction without a catalyst. A series of structurally diverse 4-oxochroman-2-carboxamides was synthesized with this one-pot protocol. In addition, the new reaction was expanded for the synthesis of a series of tetrazole substituted chromones by replacing carboxylic acid with trimethylsilyl azide (TMSN₃). The imine functional group and the corresponding aldehyde hydrolysed from the imine were utilized for further structural diversification.

中文翻译：

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通过迈克尔加成驱动的多组分反应可快速获得色酮类似物

开发了迈克尔加成驱动的四组分反应（4-CR），用于在没有催化剂的情况下通过策略性抑制竞争性4-CR Ugi反应来衍生色酮。使用此一锅方案，合成了一系列结构多样的4-氧代苯并二氢呋喃酰胺。另外，通过用三甲基甲硅烷基叠氮化物（TMSN ₃）代替羧酸，扩大了用于合成一系列四唑取代的色酮的新反应。从亚胺水解的亚胺官能团和相应的醛用于进一步的结构多样化。