The emergence of new fungal pathogens makes the development of new antifungal drugs a medical imperative that in recent years motivates the talents of numerous investigators across the world. Understanding not only the structural families of these drugs but also their biological targets provides a rational means for evaluating the merits and selectivity of new agents for fungal pathogens and normal cells. An equally important aspect of modern antifungal drug development takes a balanced look at the problems of drug potency and drug resistance. The future development of new antifungal agents will rest with those who employ synthetic and semisynthetic methodology as well as natural product isolation to tackle these problems and with those who possess a clear understanding of fungal cell architecture and drug resistance mechanisms. This review endeavors to provide an introduction to a growing and increasingly important literature, including coverage of the new developments in medicinal chemistry since 2015, and also endeavors to spark the curiosity of investigators who might enter this fascinatingly complex fungal landscape.

中文翻译：

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抗真菌药物药物化学的全面概述：观点和希望。

新的真菌病原体的出现使新的抗真菌药物的开发成为医学上的当务之急，近年来，这激发了世界各地众多研究人员的才能。不仅了解这些药物的结构家族，而且了解其生物学靶标，为评估真菌病原体和正常细胞新药的优缺点和选择性提供了一种合理的手段。现代抗真菌药物开发的一个同等重要的方面是对药效和耐药性问题的平衡研究。新型抗真菌剂的未来发展将取决于那些使用合成和半合成方法以及天然产物分离来解决这些问题的人员，以及对真菌细胞结构和耐药机制有清楚了解的人员。