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Introgression of Eastern Chinese and Southern Chinese haplotypes contributes to the improvement of fertility and immunity in European modern pigs.
GigaScience ( IF 9.2 ) Pub Date : 2020-03-01 , DOI: 10.1093/gigascience/giaa014 Hao Chen 1 , Min Huang 1 , Bin Yang 1 , Zhongping Wu 1 , Zheng Deng 1 , Yong Hou 1 , Jun Ren 1 , Lusheng Huang 1
GigaScience ( IF 9.2 ) Pub Date : 2020-03-01 , DOI: 10.1093/gigascience/giaa014 Hao Chen 1 , Min Huang 1 , Bin Yang 1 , Zhongping Wu 1 , Zheng Deng 1 , Yong Hou 1 , Jun Ren 1 , Lusheng Huang 1
Affiliation
BACKGROUND
Pigs were domesticated independently from European and Asian wild boars nearly 10,000 years ago. Chinese indigenous pigs have been historically introduced to improve Europe local pigs. However, the geographic origin and biological functions of introgressed Chinese genes in modern European pig breeds remain largely unknown.
RESULTS
Here we explored whole-genome sequencing data from 266 Eurasian wild boars and domestic pigs to produce a fine-scale map of introgression between French Large White (FLW) and Chinese pigs. We show that FLW pigs had historical admixture with both Southern Chinese (SCN) and Eastern Chinese (ECN) pigs ∼200-300 years ago. Moreover, a set of SCN haplotypes was shown to be beneficial for improving disease resistance and ECN haplotypes are favorable for improved reproductive performance in FLW pigs. In addition, we confirm human-mediated introgression events at the AHR locus, at which the haplotype of most likely ECN origin contributes to increased fertility of FLW pigs.
CONCLUSIONS
This study advances our understanding of the breeding history of global domestic pigs and highlights the importance of artificial introgression in the formation of phenotypic characteristics in domestic animals.
更新日期：2020-03-06
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