Clonocoprogens A, B and C, new antimalarial coprogens from the Okinawan fungus Clonostachys compactiuscula FKR-0021.,The Journal of Antibiotics

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Clonocoprogens A, B and C, new antimalarial coprogens from the Okinawan fungus Clonostachys compactiuscula FKR-0021.
The Journal of Antibiotics ( IF 3.3 ) Pub Date : 2020-03-06 , DOI: 10.1038/s41429-020-0292-7
Takahito Ouchi ₁ , Yoshihiro Watanabe ₂ , Kenichi Nonaka _{1,

2} , Reiko Muramatsu ₂ , Chikako Noguchi ₂ , Miho Tozawa ₂ , Rei Hokari ₂ , Aki Ishiyama _{1,

2} , Rima Koike ₃ , Hidehito Matsui ₂ , Yukihiro Asami _{1,

2} , Yuki Inahashi _{1,

2} , Takahiro Ishii ₄ , Toshiaki Teruya ₅ , Masato Iwatsuki _{1,

2} , Hideaki Hanaki ₂ , Satoshi Ōmura ₂

Affiliation

Three new antimalarial compounds, clonocoprogens A, B, and C, were isolated from the static culture of an Okinawan fungus, Clonostachys compactiuscula FKR-0021. These compounds were new analogs of N14-palmitoylcoprogen, reported as a siderophore. They showed moderate antimalarial activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum strains, with IC50 values ranging from 1.7 to 9.9 µM.

中文翻译：

Clonocoprogens A，B和C，来自冲绳真菌Clonostachys compactiuscula FKR-0021的新抗疟原虫。

从冲绳真菌Closnostachys compactiuscula FKR-0021的静态培养物中分离出三种新的抗疟疾化合物，clonocoprogens A，B和C。这些化合物是N14-棕榈酰辅酶的新类似物，据报道是铁载体。他们对氯喹敏感和耐氯喹的恶性疟原虫菌株显示出中等的抗疟活性，IC50值在1.7至9.9 µM之间。

更新日期：2020-03-06

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