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Intensified Short Symptom Screening Program for Dengue Infection during Pregnancy, India
Emerging Infectious Diseases ( IF 11.8 ) Pub Date : 2020-03-05 , DOI: 10.3201/eid2604.191476
Shilpa Naik , Matthew L. Robinson , Mallika Alexander , Ajay Chandanwale , Pradip Sambarey , Aarti Kinikar , Renu Bharadwaj , Gajanan N. Sapkal , Puja Chebrolu , Prasad Deshpande , Vandana Kulkarni , Smita Nimkar , Vidya Mave , Amita Gupta , Jyoti Mathad

Mosquitoborne diseases (e.g., malaria, dengue, and chikungunya) are endemic to India and pose diagnostic challenges during pregnancy. We evaluated an intensified short symptom screening program in India to diagnose dengue during pregnancy. During October 2017–January 2018, we screened pregnant women during antenatal surveillance for symptoms of mosquitoborne diseases (fever only, fever with conjunctivitis, fever with rash, or all 3 symptoms) within the previous 15 days . Of 5,843 pregnant women screened, 52 were enrolled and tested for dengue, chikungunya, and Zika viruses by using a Trioplex real-time reverse transcription PCR. Of 49 who had complete results, 7 (14%) were dengue positive. Ocular pain was seen in 28 (57%) and conjunctivitis in 49 (100%) of the patients with complete results. Intensified symptom screening using conjunctivitis, in addition to rash, in pregnant women with fever might improve dengue case detection and can be included in routine symptom screening during pregnancy.



中文翻译:

加强妊娠期登革热感染短期症状筛查计划,印度

蚊媒疾病(例如疟疾、登革热和基孔肯雅热)是印度的地方病,在怀孕期间对诊断提出了挑战。我们评估了印度一项强化的短期症状筛查计划,以诊断怀孕期间的登革热。在 2017 年 10 月至 2018 年 1 月期间,我们在产前监测期间筛查了孕妇在过去 15 天内的蚊媒疾病症状(仅发热、发热伴结膜炎、发热伴皮疹或所有 3 种症状)。在筛查的 5,843 名孕妇中,有 52 名被纳入并使用 Trioplex 实时逆转录 PCR 检测登革热、基孔肯雅热和寨卡病毒。在获得完整结果的 49 人中,7 人 (14%) 为登革热阳性。28 名 (57%) 患者出现眼痛,49 名 (100%) 患者出现结膜炎,结果完整。使用结膜炎加强症状筛查,

更新日期:2020-03-16
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