This study includes the synthesis of amino acid graft copolymer from N- Acryloyl-L-phenylalanine amino acid and Guar gum polymer through free radical polymerization. Then the dual responsive (pH & temperature) hydrogels are synthesized by employing free radical cross linking polymerization using graft copolymer, N-isopropyl acrylamide and 2-(dimethylamine) ethylmethacrylate using N,N′-methylenebisacrylamide as a cross-linker and ammonium per sulfate as initiator. The structural properties of the hydrogels are evaluated by the determination of various network properties such as mesh size, crosslink density, Flory-Huggins interaction parameter, volume fraction in the swollen state and the average molecular weight of the polymer chain between two neighboring cross links. Dynamic and equilibrium swelling studies of hydrogels are performed in distilled water, pH 1.20 and pH 7.40 solutions at 25 °C and 37^o ± 5 °C, swelling capacity in various salt solutions and corresponding swelling kinetic parameters are also calculated. Grafting, cross linking and structural changes are studied by fourier transform infrared and scanning electron microscope, distribution of imatinib mesylate drug in hydrogel is confirmed by X-ray diffraction, differential scanning calorimetry, thermo gravimetric analysis. Drug loading and encapsulation efficiency of Imatinib mesylate in various formulations of the hydrogels are also studied. The in-vitro drug release studies are performed in pH 1.20 and 7.40 phosphate buffer solutions at different amounts of cross linker, monomer and graft copolymer and temperature. The mode of drug release mechanism is analyzed by various kinetic models such as zero order, First order, Higuchi Square root, Hixson-Crowell cube root and Koresmeyer-Peppas equations.

这项研究包括由N-丙烯酰基-L-苯丙氨酸氨基酸和瓜尔胶聚合物通过自由基聚合合成氨基酸接枝共聚物。然后通过接枝共聚物，N-异丙基丙烯酰胺和N，N'的N-异丙基丙烯酰胺和甲基丙烯酸2-（二甲胺）乙酯的自由基交联聚合反应合成双响应（pH和温度）水凝胶。-亚甲基双丙烯酰胺作为交联剂，过硫酸铵作为引发剂。通过确定各种网络特性（例如筛孔尺寸，交联密度，Flory-Huggins相互作用参数，溶胀状态下的体积分数以及两个相邻交联之间的聚合物链的平均分子量）来评估水凝胶的结构特性。动态和水凝胶的平衡溶胀研究在蒸馏水中进行的，在25℃和37的pH 1.20和pH 7.40的解决方案^ö 还计算了±5°C，在各种盐溶液中的溶胀能力以及相应的溶胀动力学参数。通过傅里叶变换红外光谱和扫描电子显微镜研究了接枝，交联和结构变化，通过X射线衍射，差示扫描量热法，热重分析证实了甲磺酸伊马替尼药物在水凝胶中的分布。还研究了各种水凝胶制剂中甲磺酸伊马替尼的载药量和包封效率。体外药物释放研究是在pH 1.20和7.40磷酸盐缓冲溶液中，在不同数量的交联剂，单体和接枝共聚物以及温度下进行的。通过各种动力学模型（例如零阶，一阶，Hi口平方根，